ScientificBackground: | HETEsarebyproductsgeneratedbythemetabolismofarachidonicacidbylipoxygenases.12(S)-HETEisthestereospecifichydroxyproductfromthereductionof12(S)-hydroperoxytetraenoiceicosatetraenoicacid[12(S)-HpETE],whichitselfisa12-lipoxygenasemetaboliteofarachidonicacid.12(S)-HETEischemotacticandchemokineticforpolymorphonuclearleukocytesandvascularsmoothmusclecells.Italsoactsasasecondmessengerinangiotensin-IIinducedaldosteroneproduction.15-hydroxyeicosatetraenoicacid[15(S)-HETE]isthemajorhydroxyderivativeofarachidonicacidwhenacteduponby15-lipoxygenase.ItisalsotheprimarymonohydroxyacidsynthesizedbythelipoxygenaseactivityofCyclooxygenase-1uponlinoleicacid.15(S)-HETEactsasaparacrineregulatorofsmoothmuscleandlungneutrophilrecruitment,andelevatedlevelsof15(S)-HETEareassociatedwithasthma,rhinitis,chronicparanasalsinusitisandrheumatoidarthritis. |