Enzolifesciences/HSP27 monoclonal antibody (G3.1)/ADI-SPA-800-D/50µg,Enzo Life,,Enzo Life Sciences,enzolifesciences,Enzo ,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Enzolifesciences/HSP27 monoclonal antibody (G3.1)/ADI-SPA-800-D/50µg

产品编号：ADI-SPA-800-D

市场价：¥4080.00

场地：美国(厂家直采)

产品分类：分子类>其他分子产品>外泌体研究>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$204.00

品牌： Enzo Life

公司：Enzolifesciences,Inc.

公司分类：

商品介绍

Product Specification:

Alternative Name:	HspB1, Heat shock protein 27

Clone:	G3.1

Host:	Mouse

Isotype:	IgG1

Immunogen:	Native human Hsp27.

UniProt ID:	P04792

GenBank ID:	L39370

Species reactivity:	Human, Mouse, Rat Bovine, Fish, Monkey

Applications:	ELISA, ICC, IHC (PS), IP, WB Electron microscopy, in vitro Assay

Recommended Dilutions/Conditions:	Western Blot (1:1,000, colorimetric) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Detects a band of ~27kDa by Western blot.

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

品牌介绍

Enzo Biochem是分子诊断领域的先驱，通过开发独特的诊断平台技术来引领临床实验室，生命科学和知识产权的融合，该技术提供了许多超越先前标准的优势。恩佐（Enzo）是一家全球性公司，利用跨职能团队开发和部署产品系统和服务，以满足当今和未来不断变化和快速增长的医疗保健需求。Enzo产品和技术的基础是广泛而深入的知识产权产品组合，其专利涵盖了许多关键的启用技术。恩佐（Enzo）在操纵和修改遗传材料和其他生物分子方面拥有专有技术和专业知识。

公司介绍

更多...

产品分类

更多...

Antibodies

销售排行

更多...