产品编号：ADI-905-814-100
市 场 价：¥6620.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
邮 箱：
info@ebiomall.com
商品介绍
Product Specification:
| Alternative Name: | AGTR1 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of rat angiotensin II receptor AT1. |
| UniProt ID: | P25095 (AT1A), P29089 (AT1B) |
| Species reactivity: | Human, Mouse, Rat |
| Crossreactivity: | Predicted species reactivity based on epitope sequence homology: chimpanzee, bovine, rhesus macaque, sheep, dog, guinea pig, rabbit, horse, wild boar, gerbil. |
| Applications: | IHC, WB |
| Application Notes: | Predicted MW of ~41kDa. Higher MW species (~55kDa) and intermediates also observed by Western blot which reflect post-translational modification and dimerization of the receptor. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.01% sodium azide. |
| Handling: | Keep on ice at all times. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The octapeptide circulatory hormone Angiotensin II is a critical regulator of cardiovascular homeostasis formed in blood, with dual function in tissues of the brain, kidney, heart, and vasculature as an autocrine/paracrine growth hormone. The actions of angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane Gprotein coupled receptor (GPCR) family. AT1 receptors couple predominantly with Gq/11 alpha subunits, and signal through phospholipases C, D, and A2, inositol phosphates, and calcium channels, as well as a variety of serine/threonine and tyrosine kinases. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II, including regulation of arterial blood pressure, electrolyte and water balance, thirst, hormone secretion, and renal function. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing. AT2 receptor signaling is not dependent on G-protein coupling or receptor phosphorylation, although coupling to Gia2 and Gia3 alpha subunits occurs in some tissues. AT2 activation can stimulate tyrosine and serine/threonine phosphatases through activation of nitric oxide and cGMP, and appears to counteract the stimulatory effects of AT1 receptor and growth factor receptor signaling. |
| Manufacturer: | Manufactured by Proteimax. |
品牌介绍
Enzo Biochem是分子诊断领域的先驱，通过开发独特的诊断平台技术来引领临床实验室，生命科学和知识产权的融合，该技术提供了许多超越先前标准的优势。恩佐（Enzo）是一家全球性公司，利用跨职能团队开发和部署产品系统和服务，以满足当今和未来不断变化和快速增长的医疗保健需求。Enzo产品和技术的基础是广泛而深入的知识产权产品组合，其专利涵盖了许多关键的启用技术。恩佐（Enzo）在操纵和修改遗传材料和其他生物分子方面拥有专有技术和专业知识。
![Enzolifesciences/[pSer<sup>1412</sup>]Nitric oxide synthase (neuronal) (rat) polyclonal antibody/ALX-210-528-C100/100&mi](images/201711/1511479400319561488.jpg)
厂家直采
全球直采 正品优价
正品保障
厂家直发 有线跟踪
正规清关
CIF100%正规报关，提供发票
及时交付
限时必达 不达必赔
总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏ 0512-67156496（苏州）
版权信息：
© 2015- 苏州蚂蚁淘生物科技有限公司 版权所有 中国
友情链接：
联系QQ:764052152
免责声明：
本站有部分内容来自互联网，如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权，请来电或致函告之，
本网站将在规定时间内给予删除等相关处理。
本网站将在规定时间内给予删除等相关处理。
扫描二维码关注官方微信
获取最新促销及产品信息