产品编号：ADI-OSA-200-F
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商品介绍
Product Specification:
| Alternative Name: | HMOX2, Hsp32, Heat shock protein 32, Heme oxygenase 2 |
| Host: | Rabbit |
| Immunogen: | Native rat HO-2 protein, isolated from rat testes. |
| UniProt ID: | P23711 |
| GenBank ID: | J05405 |
| Species reactivity: | Human, Mouse, Rat Bovine, Crawfish, Dog, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep |
| Applications: | ICC, IHC, IP, WB |
| Recommended Dilutions/Conditions: | Western Blot (1:500, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~36kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation. |
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Enzo Biochem是分子诊断领域的先驱，通过开发独特的诊断平台技术来引领临床实验室，生命科学和知识产权的融合，该技术提供了许多超越先前标准的优势。恩佐（Enzo）是一家全球性公司，利用跨职能团队开发和部署产品系统和服务，以满足当今和未来不断变化和快速增长的医疗保健需求。Enzo产品和技术的基础是广泛而深入的知识产权产品组合，其专利涵盖了许多关键的启用技术。恩佐（Enzo）在操纵和修改遗传材料和其他生物分子方面拥有专有技术和专业知识。
![Enzolifesciences/[pSer<sup>1412</sup>]Nitric oxide synthase (neuronal) (rat) polyclonal antibody/ALX-210-528-C100/100&mi](images/201711/1511479400319561488.jpg)
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