产品编号：BML-SA227-0100
市 场 价：¥8180.00
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商品介绍
Product Specification:
| Alternative Name: | Nitric oxide synthase (neuronal), NOS I |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to aa 1414-1434 (CRSESIAFIEESKKDTDEVFSS) of human brain NOS (nNOS; NOS1). |
| UniProt ID: | P29475 |
| Species reactivity: | Human, Mouse, Rat Chicken |
| Applications: | ELISA, ICC, IF, WB |
| Recommended Dilutions/Conditions: | Western Blot (1-5 µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A-affinity purified. |
| Formulation: | Liquid. In PBS containing 0.05% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation. |
品牌介绍
Enzo Biochem是分子诊断领域的先驱，通过开发独特的诊断平台技术来引领临床实验室，生命科学和知识产权的融合，该技术提供了许多超越先前标准的优势。恩佐（Enzo）是一家全球性公司，利用跨职能团队开发和部署产品系统和服务，以满足当今和未来不断变化和快速增长的医疗保健需求。Enzo产品和技术的基础是广泛而深入的知识产权产品组合，其专利涵盖了许多关键的启用技术。恩佐（Enzo）在操纵和修改遗传材料和其他生物分子方面拥有专有技术和专业知识。
![Enzolifesciences/[pSer<sup>1412</sup>]Nitric oxide synthase (neuronal) (rat) polyclonal antibody/ALX-210-528-C100/100&mi](images/201711/1511479400319561488.jpg)
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