Enzolifesciences/Proteasome 19S Rpt1/S7 subunit monoclonal antibody (MSS1-104)/BML-PW8825-0025/25µl,Enzo Life,,Enzo Life Sciences,enzolifesciences,Enzo ,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Enzolifesciences/Proteasome 19S Rpt1/S7 subunit monoclonal antibody (MSS1-104)/BML-PW8825-0025/25µl

产品编号：BML-PW8825-0025

市场价：¥2320.00

场地：美国(厂家直采)

产品分类：分子类>其他分子产品>外泌体研究>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$116.00

品牌： Enzo Life

公司：Enzolifesciences,Inc.

公司分类：

商品介绍

ProductSpecification:

AlternativeName:	Proteasome26SsubunitATPase2,26Sproteaseregulatorysubunit7,MSS1

Clone:	MSS1-104

Host:	Mouse

Isotype:	IgG1

Immunogen:	RecombinanthumanRpt1protein.

UniProtID:	P35998

Speciesreactivity:	Human,Mouse

Specificity:	RecognizestheRpt1/S7subunitofthe19Sregulatorcomplex.

Applications:	WB

ApplicationNotes:	SingledimensionSDS-PAGEofproteasomalpreparationsfromavarietyofsourcesfollowedbyWesternblottinggivesasinglebandwitharelativemolecularweightofapproximately48kDa. Notsuitableforimmunoprecipitation.

PurityDetail:	Purified.

Formulation:	Liquid.InPBScontaining0.01%sodiumazide.

Shipping:	ShippedonBlueIce

LongTermStorage:	-20°C

ScientificBackground:	Theproteasomeiswidelyrecognisedasthecentralenzymeofnon-lysosomalproteindegradation.ItisresponsIBLeforintracellularproteinturnoveranditisalsocriticallyinvolvedinmanyregulatoryprocessesand,inhighereukaryotes,inantigenprocessing.The26Sproteasomeisthekeyenzymeoftheubiquitin/ATP-dependentpathwayofproteindegradation.Thecatalyticcoreofthisunusuallylarge(2000kDa,450Åinlength)complexisformedbythe20Sproteasome,abarrelshapedstructureshownbyelectronmicroscopytocompriseoffourringseachcontainingsevensubunits.Basedonsequencesimilarity,allfourteen20Sproteasomalsubunitsequencesmaybeclassifiedintotwogroups,αandβ,eachgrouphavingdistinctstructuralandfunctionalroles.Theα-subunitscomprisetheouterringsandtheβ-subunitstheinnerringsofthe20Sproteasome.Observationsoftheeukaryoticproteasomeandanalysisofsubunitsequencesindicatethateachringcontainssevendifferentsubunits(α7β7β7α7)withamemberofeachsub-familyrepresentedineachparticle.Eachsubunitislocatedinauniquepositionwithintheα-orβ-rings. Inadditiontothe20Sparticle,the26Scomplexcontainsovertwentyadditionalproteins,ranginginmolecularweightfrom25to10kDa,locatedinadistinctcomplexcalledthe‘PA700proteasomeactivator’orthe‘19Scomplex’,andwhichdeterminessubstratespecificityandprovidesthemultipleenzymaticfunctionsnecessaryforproteolysisandviABIlity.Systematicanalysisofthesub-unitcomponentshaverevealedatleastsixmemberstobeATPasesbelongingtoanewfamilyofATPbindingproteins,togetherwithafurtherfifteensub-unitsthatlackthecapacitytobindATP,isopeptidasesandseveralotherproteinsthoughttoberesponsiblefortheunfoldingofaproteinsubstratepriortoinsertionintotheproteolyticcoreofthe20Sproteasome.

品牌介绍

Enzo Biochem是分子诊断领域的先驱，通过开发独特的诊断平台技术来引领临床实验室，生命科学和知识产权的融合，该技术提供了许多超越先前标准的优势。恩佐（Enzo）是一家全球性公司，利用跨职能团队开发和部署产品系统和服务，以满足当今和未来不断变化和快速增长的医疗保健需求。Enzo产品和技术的基础是广泛而深入的知识产权产品组合，其专利涵盖了许多关键的启用技术。恩佐（Enzo）在操纵和修改遗传材料和其他生物分子方面拥有专有技术和专业知识。

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Antibodies

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