Enzolifesciences/Proteasome 20S β1i subunit monoclonal antibody (LMP2 - 13)/BML-PW8840-0025/25µl,Enzo Life,,Enzo Life Sciences,enzolifesciences,Enzo ,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Enzolifesciences/Proteasome 20S β1i subunit monoclonal antibody (LMP2 - 13)/BML-PW8840-0025/25µl

产品编号：BML-PW8840-0025

市场价：¥2480.00

场地：美国(厂家直采)

产品分类：分子类>其他分子产品>外泌体研究>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$124.00

品牌： Enzo Life

公司：Enzolifesciences,Inc.

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商品介绍

Product Specification:

Alternative Name:	Proteasome subunit β type-9, RING12 protein, LMP2

Clone:	LMP2-13

Host:	Mouse

Isotype:	IgG1

Immunogen:	Recombinant human β1i protein.

UniProt ID:	P28065 (human), P28077 (rat)

Gene/Protein Identifier:	PSMB9 (gene name)

Species reactivity:	Human, Rat

Specificity:	Recognizes the β1i subunit of proteasome 20S.

Applications:	IHC, WB

Application Notes:	The serum was characterised by single dimension SDS-PAGE using a HeLa cell lysate both with and without prior stimulation with γ-interferon. The mature LMP2 protein of ~22kDa was detected by Western blotting in the γ-interferon stimulated cells and additionally the precursor form at ~25kDa. Not suitable for immunoprecipitation.

Purity Detail:	Protein G-affinity purified ascites.

Formulation:	Liquid. In PBS containing 10mM sodium azide.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. Based on sequence similarity, all fourteen 20S proteasomal subunit sequences may be classified into two groups, α and β, each group having distinct structural and functional roles. The α-subunits comprise the outer rings and the β-subunits the inner rings of the 20S proteasome. Observations of the eukaryotic proteasome and analysis of subunit sequences indicate that each ring contains seven different subunits (α7β7β7α7) with a member of each sub-family represented in each particle. Each subunit is located in a unique position within the α- or β-rings. Lmp2, Lmp7 and MECL are interferon gamma-inducible catalytic subunits of the 20S proteasome which may replace the constitutive catalytic subunits, delta, X and Z respectively, during proteasome biogenesis. Lmp2 and Lmp7 alter the cleavage site specificity of the 20S proteasome and are required for the efficient generation of T cell epitopes from a number of viral proteins and for optimal MHC class I cell surface expression.

Technical Info/Product Notes:	Various systems for the nomenclature of the proteasome subunits have been established. This may be a source of confusion as the system on UniProt differs from "standard" nomenclature as described in the literature. The UniProt ID and Gene Name will help to clearly identify the proteins.

品牌介绍

Enzo Biochem是分子诊断领域的先驱，通过开发独特的诊断平台技术来引领临床实验室，生命科学和知识产权的融合，该技术提供了许多超越先前标准的优势。恩佐（Enzo）是一家全球性公司，利用跨职能团队开发和部署产品系统和服务，以满足当今和未来不断变化和快速增长的医疗保健需求。Enzo产品和技术的基础是广泛而深入的知识产权产品组合，其专利涵盖了许多关键的启用技术。恩佐（Enzo）在操纵和修改遗传材料和其他生物分子方面拥有专有技术和专业知识。

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