AlternativeName: | X-boxbindingprotein1,Tax-responsiveelement-bindingprotein5,TREB5,XBP2 |
Host: | Mouse |
Immunogen: | SyntheticpeptidecorrespondingtothesequenceneartheC-terminusofhumanXBP-1,splicedisoformXBP1(S). |
UniProtID: | P17861 |
Speciesreactivity: | Human,Mouse |
Applications: | ELISA,ICC,IP,WB |
RecommendedDilutions/Conditions: | Immunocytochemistry(1:100) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
ApplicationNotes: | Detectsabandof~60kDabyWesternblot. |
PurityDetail: | ProteinGaffinitypurified. |
Formulation: | Liquid.InPBScontaining0.09%sodiumazide. |
Handling: | Avoidfreeze/thawcycles. |
Shipping: | ShippedonBlueIce |
LongTermStorage: | -20°C |
ScientificBackground: | Xboxbindingprotein1(XBP-1)isakeyproteininthemammalianunfoldedproteinresponse(UPR)thatprotectsthecellagainstthestressofmisfoldedproteinsintheendoplasmicreticulum(ER).XBP-1mRNAissplicedbyIRE1punderERstress,resultingina371aminoacidprotein(XBP-1s)whichistranslocatedtothenucleuswhereitbindstotheregulatoryelementsofdownstreamgenes.XBP-1stimulatestheproductionofERstressproteinsincludingtheERresidentproteinchaperonesgrp78andgrp94. |